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目的探讨强直性脊柱炎(AS)与ERAP1基因多态性关联的Meta分析。方法检索已发表的有关AS与ERAP1基因多态性的文献,进行Meta分析,采用Reveman 5.0统计学软件对结果进行分析。结果 17篇文献共纳入AS患者11 411例和正常对照者16 511例。Meta分析显示,ERAP1基因rs27044、rs30187、rs10050860、rs2287987、rs17482078、rs27434和rs27037位点的罕见等位基因频率在两组间差异有统计学意义(P<0.05)。进一步分析显示,以上7个位点包含罕见等位基因的基因型频率分布在两组间差异有统计学意义(P<0.05)。结论 Meta分析显示ERAP1基因多态性与AS存在关联。
Objective To explore the association between ankylosing spondylitis (AS) and ERAP1 gene polymorphism. METHODS: The published literature on polymorphisms of AS and ERAP1 genes was searched for Meta-analysis and the results were analyzed using Reveman 5.0 statistical software. Results A total of 17 411 AS patients and 16 511 healthy controls were included in the 17 articles. Meta-analysis showed that the rare allele frequencies of ERAP1 gene rs27044, rs30187, rs10050860, rs2287987, rs17482078, rs27434 and rs27037 were significantly different between the two groups (P <0.05). Further analysis showed that the frequency distribution of the above seven loci containing rare alleles was statistically different between the two groups (P <0.05). Conclusions Meta-analysis shows that ERAP1 gene polymorphism is associated with AS.