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目的明确血浆氨基末端-脑钠肽前体(NT-pro-BNP)、肌钙蛋白I(cTnI)、纤维凝血酶原片段1+2(F1+2)的测定对诊断肺血栓栓塞症价值。方法选择38例肺栓塞(PE)患者为PE组,同期选择年龄、性别相匹配的健康者40例为正常对照组。分别测定NT-pro-BNP、cTnI、F1+2值。采用全自动免疫测定装置AIA360以荧光磁微粒酶免法测定cTnI,Cobas e610免疫分析仪用电化学发光法测定NT-pro-BNP,Elisa法测定F1+2值。结果两组间NT-pro-BNP、cTnI、F1+2值均有统计学差异。PE组血浆NT-pro-BNP为(2418.26±2916.53)pg/L,对照组为(93.80±45.69)pg/L,两组比较差异有统计学意义(P<0.01);PE组血浆cTnI为(1.39±1.27)ng/ml,对照组为(0.28±0.61)ng/ml,两组比较差异有统计学意义(P<0.05);PE组血浆F1+2为(146.84±97.83)nmol/L,对照组为(90.62±20.28)nmol/L,两组比较差异有统计学意义(P<0.05)。结论 PE患者血浆NT-pro-BNP、cTnI、F1+2浓度明显升高,这对PE的诊断有实际临床意义。
Objective To determine the value of plasma NT-pro-BNP, cTnI, and fibrinogen fragment 1 + 2 (F1 + 2) in the diagnosis of pulmonary thromboembolism. Methods Forty-eight PE patients were selected as PE group. Forty healthy subjects with matched age and gender were selected as normal control group. NT-pro-BNP, cTnI, F1 + 2 values were measured respectively. The cTnI assay was performed with an automated immunoassay device, AIA360, and the Cobas e610 immunoassay was used to determine NT-pro-BNP by electrochemiluminescence. The F1 +2 values were determined by the Elisa method. Results There were significant differences in NT-pro-BNP, cTnI and F1 + 2 between the two groups. The level of plasma NT-pro-BNP in PE group was (2418.26 ± 2916.53) pg / L and that in control group was (93.80 ± 45.69) pg / L, the difference was statistically significant (1.39 ± 1.27) ng / ml in the control group and (0.28 ± 0.61) ng / ml in the control group, the difference between the two groups was statistically significant (P <0.05); the level of F1 + 2 in the PE group was (146.84 ± 97.83) nmol / The control group was (90.62 ± 20.28) nmol / L, the difference between the two groups was statistically significant (P <0.05). Conclusion The plasma levels of NT-pro-BNP, cTnI and F1 + 2 in patients with PE are significantly increased, which has practical clinical significance in the diagnosis of PE.