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目的:探讨阿昔洛韦联合纳洛酮治疗小儿病毒性脑炎疗效及安全性。方法:选取我院治疗的病毒性脑炎小儿患者80例,随机分为观察组和对照组(n=40),观察组采用阿昔洛韦联合纳洛酮治疗,对照组单纯使用阿昔洛韦治疗,比较两组患儿的总治疗有效率、治疗后不良反应发生情况及后遗症情况。结果:总有效率观察组(95.0%)治疗高于对照组(77.5%),差异有统计学意义(p<0.05);观察组不良反应发生率、后遗症发生率均低于对照组,数据组间均有显著差异(P<0.05),具有统计学意义。结论:阿昔洛韦联合纳洛酮治疗小儿病毒性脑炎相比单独用药,疗效更好、不良反应低且无明显后遗症发生,值得临床推广应用。
Objective: To investigate the efficacy and safety of acyclovir and naloxone in the treatment of viral encephalitis in children. Methods: Eighty children with viral encephalitis treated in our hospital were randomly divided into observation group and control group (n = 40). The observation group was treated with acyclovir combined with naloxone. The control group was treated with acyclovir only Wei treatment, the two groups were compared the total effective rate of treatment, the incidence of adverse reactions after treatment and sequelae. Results: The total effective rate of observation group (95.0%) was higher than that of the control group (77.5%), the difference was statistically significant (p <0.05). The incidence of adverse reactions and sequelae in observation group were lower than those in control group and data group There was significant difference (P <0.05), with statistical significance. Conclusion: Acyclovir combined with naloxone in children with viral encephalitis compared with single drug treatment, better efficacy, low adverse reactions and no obvious sequelae, worthy of clinical application.