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女性乳腺系内分泌激素——雌、孕激素的靶器官,其组织结构变化受激素影响具有周期性特征,这些特征反映在乳腺实质细胞的分化、成熟甚至变异等方面。除激素因素直接作用外,细胞外环境如细胞外基质成分的变化亦是重要的影响因素之一。研究证明,任何组织中细胞外基质蛋白对组织细胞的发育、成熟、分化、修复、变异甚至恶变起着调节作用。胶原蛋白为细胞外基质中含量最丰富的一类蛋白质,至少有16种类型。目前研究较多并已证实Ⅰ型胶原蛋白主要分布于结缔组织中,而Ⅳ型胶原蛋白仅见于组织基底膜内[1-3]。虽然有关
Female mammary gland endocrine hormone - estrogen and progesterone target organs, the structural changes of hormones affected by cyclical characteristics of these characteristics are reflected in the breast parenchymal cells differentiation, maturation or even mutation and so on. In addition to the direct role of hormonal factors, the extracellular environment such as extracellular matrix changes in composition is also one of the important factors. Studies have shown that extracellular matrix proteins in any tissue play a regulatory role in the development, maturation, differentiation, repair, mutation and even malignancy of tissue cells. Collagen is the most abundant type of protein in the extracellular matrix, with at least 16 types. At present, there are more studies and it has been confirmed that type I collagen is mainly distributed in connective tissue, whereas type IV collagen is found only in tissue basement membrane [1-3]. Although relevant