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目的探讨盐酸阿莫罗芬搽剂联合伊曲康唑治疗甲真菌病患者的临床疗效。方法选取2014年7月至2015年7月我院收治的的74例甲真菌病患者为研究对象,采用随机数字表法将其分为对照组和观察组,各37例。对照组患者给予盐酸阿莫罗芬搽剂联合特比萘芬进行治疗,观察组患者采用盐酸阿莫罗芬搽剂联合伊曲康唑进行治疗,比较两组患者停药时及停药半年后疗效、病菌清除率。结果疗程结束后半年,观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后病菌清除率为94.6%(35/37),明显高于对照组的78.4%(29/37),差异有统计学意义(χ2=4.1625,P<0.05)。结论盐酸阿莫罗芬搽剂联合伊曲康唑治疗甲真菌病患者的远期疗效显著,可有效清除病菌。
Objective To investigate the clinical efficacy of amorolfine hydrochloride liniment combined with itraconazole in the treatment of patients with onychomycosis. Methods Totally 74 patients with onychomycosis treated in our hospital from July 2014 to July 2015 were selected as study subjects and divided into control group and observation group with 37 cases in each group by random number table method. Patients in the control group were treated with amorolfine hydrochloride liniment combined with terbinafine. Patients in the observation group were treated with amorolfine hydrochloride liniment and itraconazole. When the patients in the two groups were stopped and the drug was stopped for six months Efficacy, bacteria clearance rate. Results Six months after the end of treatment, the total effective rate of treatment in observation group was significantly higher than that in control group (P <0.05). The clearance rate of bacteria in observation group was 94.6% (35/37) after treatment, which was significantly higher 78.4% (29/37) of the control group, the difference was statistically significant (χ2 = 4.1625, P <0.05). Conclusion Amorpholol hydrochloride liniment combined with itraconazole in treating patients with onychomycosis has a long-term curative effect, which can effectively remove bacteria.