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目的探讨广藿香油对小鼠白色念珠菌阴道炎的治疗作用。方法采用倍比稀释法测定广藿香油对白色念珠菌的体外抑菌活性;构建小鼠白色念珠菌阴道炎模型,观测广藿香油对模型小鼠阴道菌落数以及病程的影响。结果广藿香油对白色念珠菌有很好的体外抑菌活性,MICs为0.07~0.27mg/ml,且对阳性对照药克霉唑无效的3株病原菌仍然有很好的抑菌活性;与模型组比较,能明显减少模型小鼠的阴道菌落数,且可明显缩短模型小鼠的病程。结论广藿香油对白色念珠菌有很好的体外抑菌活性,对白色念珠菌阴道炎模型小鼠有很好的治疗作用,有成为治疗念珠菌性阴道炎新型药物的潜力。
Objective To investigate the therapeutic effect of patchouli oil on Candida albicans vaginitis in mice. Methods The antibacterial activity of patchouli oil against Candida albicans was determined by fold dilution method. The mouse Candida albicans vaginitis model was constructed and the effects of patchouli oil on vaginal colonies and duration were observed. Results Patchouli oil had a good antibacterial activity against Candida albicans in vitro with MICs ranging from 0.07 to 0.27 mg / ml. The three pathogenic fungi, which had no effect on the positive control drug clotrimazole, still had good antibacterial activity. Compared with the model Group, can significantly reduce the number of vaginal bacteria in model mice, and can significantly shorten the duration of the model mice. Conclusion Patchouli oil has a good antibacterial activity against Candida albicans in vitro and has a good therapeutic effect on Candida albicans vaginitis model mice and has the potential to become a new drug for treating candida vaginitis.