论文部分内容阅读
目的:研究体外过敏原与潮气呼吸肺功能测定在喘息性支气管炎中的作用。方法:喘息性支气管炎(喘支组)86例、婴幼儿哮喘(哮喘组)81例、支气管肺炎(肺炎组)72例纳入本次研究。应用瑞典Pharmacia UniCAP免疫检测分析仪,进行吸入过敏原、食入过敏原筛查,同时检测尘螨特异性IgE、血总IgE和血嗜酸性粒细胞阳离子蛋白(ECP)。患儿镇静后进行潮气呼吸肺功能检测,主要测定参数为每公斤体重潮气量(VT)、达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)。结果:喘支组与哮喘组吸入过敏原、食入过敏原阳性率和总IgE水平均高于肺炎组;喘支组VT值、TPTEF/TE值、VPTEF/VE值与哮喘组相比,差异无统计学意义;血ECP水平哮喘组大于喘支组大于肺炎组,哮喘组和喘支组血ECP与TPTEF/TE、VPTEF/VE均呈负相关。结论:通过检测过敏原、ECP和肺功能,有助于了解喘息性支气管炎气道炎症变化及肺部阻塞情况。
OBJECTIVE: To study the role of in vitro allergen and tidal respiratory function in asthmatic bronchitis. Methods: 86 cases of asthmatic bronchitis (asthma group), 81 cases of infant asthma (asthma group) and 72 cases of bronchopneumonia (pneumonia group) were included in this study. The Swedish Pharmacia UniCAP immunoassay analyzer was used for allergen inhalation and food allergy screening. Dust mite specific IgE, total blood serum IgE and blood eosinophilic cationic protein (ECP) were also detected. After the sedation, the tidal respiratory function was measured. The main parameters were VT, TPTEF / TE and VPTEF / VE. Results: The positive rates of asthma and allergic asthma were higher in asthmatic group and asthma group than those in pneumonia group. The difference of VT value, TPTEF / TE value and VPTEF / VE value between asthmatic group and asthmatic group were significant There was no significant difference between two groups. ECP level in blood was higher in asthma group than in asthmatic group, but ECP was negatively correlated with TPTEF / TE and VPTEF / VE in asthmatic group and asthmatic group. CONCLUSIONS: Allergen, ECP, and pulmonary function tests may help to understand the airway inflammation and pulmonary obstruction of asthmatic bronchitis.