研究药物的局部杭感染作用需要有合用的动物模型进行实验。曾有很多学者报导了用不同动物和不同感染方法的实验桔果。Morgenroth等、Hunt、Grunberg等、Schnitzer,和刘文富等曾采用了小白鼠腹部皮内感染的方法,认为可用于测定药物的局部抗感染作用和作用机制的研究。刘文富等在Selbie等的工作基础上用小白鼠后肢肌肉内感染的方法,观察药物的局部抗菌作用。Hartmann用家兔皮内注入葡萄球菌和药物混悬液的方法观察了磺胺呲啶钠和磺胺噻唑的抗菌作用。Collier等建立了豚鼠皮内感 Investigating the local hang-infection of drugs requires a combination of animal models for experimentation. There have been many scholars reported the experimental orange fruit with different animals and different methods of infection. Morgenroth et al., Hunt, Grunberg et al., Schnitzer, and Liu Weifu et al., Used a method of intradermal infection of the abdomen in mice and considered that they could be used to determine the local anti-infective effect and mechanism of action of the drug. Liu Wenfu and other work on the basis of Selbie and other mouse hindlimb infection with the method of observation of local antibacterial drugs. Hartmann injected rabbits intradermal staphylococcus aureus and drug suspension method to observe the sulfadiazine sodium and sulfathiazole antibacterial effect. Collier et al. Established guinea pig dermis