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目的 观察严重急性呼吸综合征 (severeacuterespiratorysyndrome ,SARS)患者体内炎性细胞因子 (IL 12P70、IL 1β、TNF α、IL 6、IL 8)和抗炎因子 (IL 10 )在疾病进程中的反应及探讨其临床意义。方法 将处于一系列年龄段的 4 7个SARS患者分为 2组 :治愈组 (n =2 7) ,死亡组 (n =2 0 ) ,另设正常对照组 (n =10 ) ;用BDCBA(Cytometricbeadarray)的方法对上述 6种细胞因子进行分析检测 ,用统计学分析软件SPSS10 .0进行统计分析。结果 所有 4 7名患者炎性因子 (IL 12P70、IL 1β、TNF α、IL 6、IL 8)和抗炎细胞因子 (IL 10 )较正常对照组均显著升高 (P <0 .0 5 ) ;死亡组IL 12P70、IL 1β、TNF α、IL 6、IL 8和IL 10较治愈组显著升高 (P <0 .0 5 )。对治愈组而言 ,IL 6在发病 2～ 12d(中位数 7d)达到峰值 ,之后呈显著下降趋势 (P <0 .0 5 ) ;而IL 8则在发病后 8～ 19d(中位数 13d)达到最高 ,之后显著下降 (P <0 .0 5 ) ;相应地 ,IL 6 IL 10在发病后 2～ 12d(中位数 7d)显著高于发病后 8～ 19d(中位数 13d)和恢复期比值。结论 高浓度的血浆炎性因子 (IL 12P70、IL 1β、TNF α、IL 6、IL 8)和抗炎因子 (IL 10 )提示发生在SARS患者的严重炎性和抗炎反应 ;IL 6是早期炎性反应中的主要炎性因子 ,可能对?
Objective To investigate the response of inflammatory cytokines (IL 12P70, IL 1β, TNFα, IL 6, IL 8) and anti-inflammatory cytokines (IL 10) in the pathogenesis of severe acute respiratory syndrome (SARS) Its clinical significance. Methods A total of 47 SARS patients in a series of age groups were divided into two groups: the cured group (n = 27), the death group (n = 20) and the normal control group (n = 10) Cytometricbeadarray) method for the above six kinds of cytokines were analyzed and detected using statistical analysis software SPSS10 .0 for statistical analysis. Results The inflammatory factors (IL 12P70, IL 1β, TNFα, IL 6, IL 8) and anti-inflammatory cytokines (IL 10) in all 47 patients were significantly higher than those in the normal controls (P 0.05) . The levels of IL 12P70, IL 1β, TNFα, IL 6, IL 8 and IL 10 in the death group were significantly higher than those in the cured group (P <0.05). For the healing group, IL 6 peaked at 2 to 12 days (median 7 days) and then decreased significantly (P <0.05), whereas IL 8 increased from 8 to 19 days after onset (median (P <0.05). IL 6 IL 10 was significantly higher at 2 ~ 12 days (median 7 days) than that at 8 ~ 19 days after onset (median 13 days) And recovery period ratio. Conclusions High concentrations of plasma inflammatory cytokines (IL 12P70, IL 1β, TNFα, IL 6, IL 8) and anti-inflammatory cytokines (IL 10) suggest severe inflammatory and anti-inflammatory reactions in SARS patients; IL 6 is an early The main inflammatory factor in the inflammatory response may be?