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目的:观察贯郁胶囊的抗抑郁作用。方法:小鼠悬尾、小鼠强迫游泳及利血平拮抗实验。结果:贯郁胶囊1. 2g kg、0. 6g kg均可显著缩短小鼠悬尾及强迫游泳不动时间(P <0 . 0 1,P <0. 0 5 ) ,并且均可显著对抗利血平所致的小鼠体温下降、眼睑下垂及运动不能(P <0. 0 1,P <0. 0 5 )。结论:贯郁胶囊具有明显的抗抑郁作用。
Objective: To observe the antidepressant effect of Guanyu Capsule. Methods: Mouse tail suspension, forced swimming in mice and reserpine antagonistic experiments. RESULTS: Both 1.2 g kg and 0.6 g kg of Guanyu capsule could significantly shorten the tail suspension and forced swimming immobility time (P < 0.01, P <0.05), and they could all significantly contradict the benefits. Hemodialysis caused a decrease in body temperature, drooping eyelids, and movement (P < 0.01, P <0.05). Conclusion: Guanyu Capsule has obvious antidepressant effect.