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目的:目的:分析染色体长臂次缢痕增加(qh+)与生殖异常的临床效应关系。方法:对2080例不孕不育患者进行常规外周血染色体核型分析。结果:2080例不孕不育患者共检出染色体多态性208例,检出率为10.0%,其中qh+患者88例,占42.31%。88例qh+患者中,男性72例,女性16例。1qh+22例;9qh+17例;16qh+14例;Yqh+(46,XY,大Y)29例;46,XY,Yqh+,9qh+5例;46,XY,Yqh+,16qh+患者1例。72例男性患者中存在精子质量问题者60例,占83.33%。配偶有胚胎停育史者共12例,占16.7%,其中2次以上胚胎停育史者共8例,占11.11%;配偶有畸形儿生育史者3例。16例女性患者中有胚胎停育史者7例(43.12%),其中2次以上胚胎停育史者5例(31.25%)。结论:染色体qh+与不孕不育、复发性流产、生育畸形儿等生殖异常存在明显的相关性,不能忽视其临床效应。
Objective: To analyze the relationship between the increase of qh + and the clinical effect of reproductive abnormalities on chromosomes. Methods: 2080 cases of infertility patients with conventional peripheral blood chromosome karyotype analysis. Results: A total of 208 chromosomes were detected in 2080 cases of infertility, the detection rate was 10.0%, of which 88 cases were qh + (42.31%). 88 cases of qh + patients, 72 males and 16 females. There were 29 patients with 1qh + 22 cases, 9qh + 17 cases, 16qh + 14 cases, 29 cases with Yqh + (46, XY, large Y), 46 cases with XY, Yqh + and 9qh + There were 60 cases of sperm quality problems in 72 male patients, accounting for 83.33%. Spouses have a history of embryo off a total of 12 cases, accounting for 16.7%, of which 2 or more of the history of embryo off a total of 8 cases, accounting for 11.11%; maternal spawning history of deformed children in 3 cases. There were 7 patients (43.12%) with histopathology in 16 female patients, among which 5 patients (31.25%) had two or more episodes of embryo shutdown. Conclusion: Chromosome qh + and infertility, recurrent spontaneous abortion and reproductive abnormalities such as reproductive abnormalities there is a clear correlation, we can not ignore the clinical effect.