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目的探讨阿奇霉素所致不良反应(ADR)的特点,指导临床安全用药。方法检索2002年1月至2010年5月国内公开发行的主要医药期刊报道的阿奇霉素的不良反应文献,选择阿奇霉素经静脉滴注给药发生ADR病例进行统计和分析。结果静脉滴注阿奇霉素所致ADR可累及全身多系统,以变态反应为主,胃肠道反应及神经系统症状次之;ADR发生于用药后10s～5d,发生在用药30min内者24例,占48%。结论临床医生应重视阿奇霉素不良反应的监测,合理使用以减少其不良反应的发生。
Objective To investigate the characteristics of azithromycin-induced adverse reactions (ADRs) and guide clinical safety medication. Methods The data of adverse reactions of azithromycin reported in the major domestic medical journals published from January 2002 to May 2010 were retrieved and the cases of ADR were selected for statistics and analysis. Results ADR induced by intravenous infusion of azithromycin can affect the whole body and multiple systems, with allergic reactions as the main, followed by gastrointestinal reactions and neurological symptoms. ADR occurred in 10 to 5 days after treatment, 24 cases occurred within 30 minutes 48%. Conclusion Clinicians should pay attention to the monitoring of azithromycin adverse reactions, rational use to reduce the incidence of adverse reactions.