【摘 要】
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目的 观察婴幼儿血管瘤中巨噬细胞的分布及其表型变化过程.方法 收集手术切除的婴幼儿血管瘤标本43例,分别使用CD68、CD16/32、CD163标记非特异性巨噬细胞、M1和M2型巨噬细胞
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目的 观察婴幼儿血管瘤中巨噬细胞的分布及其表型变化过程.方法 收集手术切除的婴幼儿血管瘤标本43例,分别使用CD68、CD16/32、CD163标记非特异性巨噬细胞、M1和M2型巨噬细胞,免疫组化染色观察其在血管瘤组织中的分布及变化.结果 ①CD68阳性巨噬细胞在增生早期大量出现,聚集于婴幼儿血管瘤新生血管的周围;增生中期数量减少,弥散于瘤体中;增生晚期和消退早期,数量进一步减少,散落于瘤体中.②M2型巨噬细胞在小于3个月的血管瘤标本中表达明显,在大于3个月的标本中迅速减少.③M1型巨噬细胞在部分增生晚期和消退早期标本中表达明显.结论 巨噬细胞参与了婴幼儿血管瘤的增殖与消退过程;早期出现的巨噬细胞为M2型,在增殖中扮演重要角色;M1型巨噬细胞可能参与消退过程.
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