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乳腺癌放疗后的复发与肿瘤细胞的辐射抗性有关。已经发现有多种因素影响着细胞的辐射抗性,这些因素包括胰岛素样生长因子受体、磷脂酰肌醇3-激酶途径、表皮生长因子、人表皮生长因子受体和血管内皮生长因子等细胞核外因素,还有p53、c-erb B2、Bcl-2、BRCA1和BRCA2基因以及端粒和基因表达谱改变等细胞核内因素。
Breast cancer recurrence after radiotherapy and tumor cell radiation resistance. A number of factors have been found to affect cellular radiation resistance, including insulin-like growth factor receptor, phosphatidylinositol 3-kinase pathway, epidermal growth factor, human epidermal growth factor receptor and vascular endothelial growth factor External factors, as well as nuclear factors such as p53, c-erb B2, Bcl-2, BRCA1 and BRCA2 genes, and changes in telomere and gene expression profiles.