[目的]探讨立止血联合法莫替丁治疗新生儿消化道出血的临床疗效。[方法]选择2008年5月～2010年5月在某院收治的消化道出血患儿96例,按随机数字表法分为观察组和对照组各48例。采用立止血联合法莫替丁,对照组给予止血敏。观察两组新生儿消化道出血止血时间、临床疗效和不良反应。[结果]观察组止血时间为(1.5±0.2)d,明显低于对照组的(3.2±0.7)d,差异有统计学意义(P﹤0.05);观察组总有效率为93.7%(45/48),明显高于对照组的75.0%(36/48),差异有统计学意义(χ2=6.40,P﹤0.05);观察组未见不良反应。[结论]立止血联合法莫替丁治疗新生儿消化道出血,疗效确切、止血迅速、简单方便,且无不良反应,值得临床推广应用。 [Objective] To investigate the clinical efficacy of Liqun combined with famotidine in the treatment of neonatal gastrointestinal bleeding. [Method] Ninety-six children with gastrointestinal bleeding admitted to a hospital from May 2008 to May 2010 were divided into observation group (48 cases) and control group (48 cases) according to random number table. Antithrombotic combined with famotidine, the control group given hemostatic sensitivity. Two groups of neonatal gastrointestinal bleeding time, clinical efficacy and adverse reactions were observed. [Results] The bleeding time in observation group was (1.5 ± 0.2) days, which was significantly lower than that in control group (3.2 ± 0.7 days) (P <0.05). The total effective rate in observation group was 93.7% (45 / 48), which was significantly higher than that of the control group (75.0%, 36/48), the difference was statistically significant (χ2 = 6.40, P <0.05). No adverse reactions were observed in the observation group. [Conclusion] Rhizoma Bletillae combined with famotidine in the treatment of neonatal gastrointestinal bleeding has definite curative effect, rapid hemostasis, simple and convenient, and no adverse reactions, which is worth popularizing and clinical application.