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在淋巴细胞发育过程中,编码免疫球蛋白和T细胞受体抗原结合域的基因是由彼此分离的基因片段通过V(D)J重组组装而成的。在V(D)J重组过程中会产生DNA双链断裂,并通过非同源末端连接途径完成断链末端的连接。本文概述了V(D)J重组过程中的非同源末端连接途径,并就其不同于外源性物理、化学因素诱导产生的DNA双链断裂非同源末端连接修复途径加以综述。
During lymphocyte development, genes encoding immunoglobulin and T cell receptor antigen binding domains are recombinantly assembled by V (D) J from gene fragments isolated from each other. During the recombination of V (D) J, DNA double-strand breaks will be generated and the linkage of the chain scission ends will be completed through the non-homologous end joining pathway. This review summarizes the non-homologous end-joining pathways in the V (D) J recombination process and reviews its non-homologous end-joining repair pathways that are different from exogenous physical and chemical induced DNA double-strand breaks.