良性前列腺增生(BPH)发生与细胞凋亡减少密切相关。存活素(survivin)是凋亡抑制家族的成员,是迄今为止发现的最强凋亡抑制因子。survivin可通过多种途径抑制细胞凋亡,是凋亡调控过程中的关键因子。丝裂原激活蛋白激酶(MAPK)是细胞内信号传递途径的共同通道和汇聚点。目 The occurrence of benign prostatic hyperplasia (BPH) is closely related to the decrease of apoptosis. Survivin, a member of the apoptosis-inhibiting family, is by far the strongest inhibitor of apoptosis. Survivin can inhibit apoptosis in a variety of ways and is a key factor in the process of apoptosis regulation. Mitogen-activated protein kinase (MAPK) is the common pathway and focal point for intracellular signaling pathways. Head