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目的:将延妇春开发成治疗妇女更年期综合征的新药,证实该药的药理作用。方法:选用12～14月龄动情周期紊乱的雌性大鼠进行实验,实验分延妇春5.0、10g·kg-1;更年安1.1g·kg-1,模型组及青年对照组;分别给大鼠连续灌胃延妇春5.0g·kg-1.延妇春10g·kg-1;更年安1.1g·kg-1及等量蒸馏水22天。结果:延妇春可使12～14月龄的雌性大鼠血清E2水平升高,血浆ACTH升高;使其下丘脑NA、DA含量升高,5-HT/DA、5-HT/NA比值降低,同时还可增加大鼠肾上腺重量。结论:延妇春可调节动情周期紊乱的雌性大鼠的神经内分泌。可能有利于临床治疗妇女更年期综合征
Objective: To develop Yanwuchun as a new drug for the treatment of menopausal syndrome in women and to verify its pharmacological effects. METHODS: Female rats aged 12 to 14 months with estrus disorder were selected for the experiment. The experiment was divided into the extension of Hiromi, 5.0 and 10 g·kg-1, and Gengnian, 1.1 g·kg-1, model group and young control group. The rats were continuously fed with Yanfuchun 5.0 g·kg-1. Yanfuchun 10 g·kg-1, Gengnian 1.1 g·kg-1 and the same amount of distilled water for 22 days. RESULTS: Yanfuchun could increase serum E2 level and increase plasma ACTH level in 12- to 14-month-old female rats; increase NA, DA content in hypothalamus, and 5-HT/DA and 5-HT/NA ratios. Lower, but also increase the weight of adrenal glands in rats. Conclusion: Yanfuchun can regulate the neuroendocrine of estrous cycle female rats. May be helpful for clinical treatment of women’s menopausal syndrome