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探讨了手性源 (R) (- ) 5 [(1R) 孟氧基 ] 2 (5H) 呋喃酮与氨基噻唑类化合物的不对称Michael加成反应 ,并利用该反应合成了 6个新型手性环丁内酯取代的氨基噻二唑类化合物 ,所有产物均经过1HNMR、IR、旋光度和元素分析等给予确证 .结果显示氨基噻唑中的氨基主要是从孟氧基所在位置的反面进攻 β 碳原子 .
The asymmetric Michael addition of chiral (R) (-) 5 [(1R) menthoxy] 2 (5H) furanone to aminothiazoles was investigated. Six novel chiral Cyclobutyrolactone substituted aminothiadiazole compounds, all products were confirmed by 1HNMR, IR, optical rotation and elemental analysis, etc. The results show that amino thiazole amino mainly from the location of the back of Meng Yuan attack β carbon Atom