目的 :观察恶性血液病患者使用粒细胞集落刺激因子 ( G- CSF)后对血清乳酸脱氢酶 ( L DH)、碱性磷酸酶 ( AL P)及 β2 微球蛋白 ( β2 - MG)的影响。方法 :将化疗后的恶性血液病患者分为治疗组及对照组 ,观察随白细胞升高 L DH、AL P、β2 - MG的变化。结果 :随着白细胞的升高 ,L DH、AL P也上升 ,而 β2 - MG无变化。结论 :当将L DH、AL P作为肿瘤指标时 ,要注意与由 G- CSF引起的 L DH、AL P升高相区分 ,避免对疾病的疗效及预后作出错误的判断 Objective: To observe the effects of G-CSF on the serum levels of L DH, ALP and β2-MG in patients with hematologic malignancies . Methods: The patients with hematologic malignancies after chemotherapy were divided into treatment group and control group, and the changes of L DH, AL P and β2 - MG were observed with leukocytosis. Results: With the increase of leukocytes, L DH and AL P also increased, while β2 - MG did not change. CONCLUSIONS: When using L DH and AL P as tumor markers, care should be taken to distinguish them from the increase in L DH and AL P caused by G-CSF and to avoid making false judgments on the efficacy and prognosis of the disease