各种慢性肾疾病,无论其原发病如何,其病变常逐渐进展为肾小球硬化和肾小管间质纤维化,导致慢性肾衰竭,多种细胞及细胞因子形成相互作用的复杂调控网络并恶性循环,共同参与这一过程[1]。起始阶段可为肾组织局部炎症,随后出现细胞增殖和细胞外基质沉积,最终导致肾小球硬化和肾间 Various chronic kidney diseases, regardless of their primary disease, often progress to glomerulosclerosis and tubulointerstitial fibrosis, resulting in a complex regulatory network of chronic renal failure, multiple cell and cytokine interactions Vicious circle, to participate in this process [1]. The initial stage may be local inflammation of the kidney tissue, followed by cell proliferation and extracellular matrix deposition, eventually leading to glomerulosclerosis and interrenal