论文部分内容阅读
目的研究乳胶过敏的发病机制,探讨其在职业病防治中的意义。方法统计分析上海仁济医院过敏性疾病防治中心651例门诊患者常见过敏原皮肤点刺试验(SPT)结果;再按门诊号随机选择64例乳胶SPT阳性患者,并以30例无过敏性疾病及其家族史的正常人作为对照,采用纸片法ELISA和Western-blot测定血清中乳胶特异性IgE(sIgE)。结果门诊过敏性疾病患者乳胶SPT的阳性率(37.5%)较高;乳胶过敏高危人群乳胶sIgE的阳性率(39%)高于非高危人群(16%)和正常对照(0%),差异有统计学意义(P<0.05,P<0.01);过敏患者血清可与乳胶手套浸出液中的多种成分反应。结论乳胶是过敏性疾病患者常见致敏原之一,IgE介导的速发反应是乳胶过敏的常见形式之一,高危人群应进行乳胶过敏检查,以便适当进行职业防护和日常保护。
Objective To study the pathogenesis of latex allergy and to explore its significance in the prevention and treatment of occupational diseases. Methods Statistical analysis of 651 outpatients with allergic skin prick test (SPT) results in Shanghai Renji Hospital allergic disease prevention and treatment center; randomly selected 64 patients with latex SPT positive outpatient number, and 30 cases of non-allergic diseases and As a control, normal subjects with a family history of serum-specific IgE (sIgE) were assayed by diskette ELISA and Western-blot. Results The positive rate of latex SPT in outpatients with allergic diseases was higher (37.5%). The positive rate of latex sIgE in high-risk latex allergy patients (39%) was higher than that in non-high-risk patients (16%) and normal controls Statistical significance (P <0.05, P <0.01); serum of allergic patients could react with many components of latex glove leachate. Conclusion Latex is one of the most common allergens in patients with allergic diseases. IgE-mediated immediate hypersensitivity is one of the most common forms of latex allergy. Late-onset allergy tests should be conducted in high-risk groups so that occupational protection and daily routine protection are appropriate.