p5 3基因突变是肺癌中最常见的遗传改变 ,与肺癌发生、发展关系密切。现就抑癌基因p5 3与肺癌的预后、淋巴结转移、放疗敏感性及肺癌的基因治疗研究进展作一综述 p5 3 gene mutation is the most common genetic change in lung cancer, and lung cancer occurrence and development are closely related. A review is given on the research progress of the tumor suppressor gene p5 3 and prognosis of lung cancer, lymph node metastasis, radiosensitivity and gene therapy of lung cancer