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1990年WolffJA等意外发现小鼠骨骼肌细胞能直接摄取病毒裸露的DNA ,并表达其编码的蛋白质 ,这种表达可持续数月 ,这一发现为开创基因疫苗的研究奠定了基础。 1992年Tang等将带有人生长激素的质粒DNA通过基因枪导入小鼠表皮细胞 ,几周后 88%被接种的小鼠产生了特异性抗体。 1993
In 1990, WolffJA and other accidental discovery of mouse skeletal muscle cells can directly capture the naked DNA of the virus and express its encoded protein for several months. This finding laid the foundation for the gene vaccination research. In 1992, Tang et al. Introduced plasmid DNA containing human growth hormone into mouse epidermal cells through a gene gun. After a few weeks, 88% of vaccinated mice developed specific antibodies. 1993