雷公藤醋酸乙酯提取物(50mg/kg)可明显降低小鼠血浆cGMP含量(P<0.001),其cAMP/cGMP比值明显高于对照组(P<0.05);剂量减半,脾脏中cGMP含量亦明显下降(P<0.05),其cAMP/cGMP比值亦较对照组升高。药物对脾细胞中cGMP水平的影响与其免疫抑制作用是一致的。推测醋酸乙酯提取物降低免疫功能细胞cGMP水平,从而增强机体对自身抗原的耐受性,这可能就是其治疗类风湿性关节炎等自身免疫疾病的作用机理之一。 Tripterygium ethyl acetate extract (50mg/kg) can significantly reduce the plasma cGMP content in mice (P<0.001), its cAMP/cGMP ratio was significantly higher than the control group (P<0.05); half the dose, spleen cGMP content It also decreased significantly (P<0.05). The cAMP/cGMP ratio was also higher than that of the control group. The effect of drugs on cGMP levels in splenocytes is consistent with their immunosuppressive effects. It is presumed that ethyl acetate extract reduces the cGMP level of immune cells, thereby enhancing the body’s tolerance to autoantigens, which may be one of the mechanisms of its action in the treatment of autoimmune diseases such as rheumatoid arthritis.