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目的:研究喉鳞状细胞癌(LSCC)组织中细胞黏附分子CD44变构体6(CD44v6)和基质金属蛋白酶-9(MMP-9)的表达情况及临床意义。方法:应用免疫组织化学SABC法测定27例LSCC组织及8例癌旁正常喉黏膜组织中CD44v6和MMP-9的表达,并分析CD44v6和MMP-9表达与LSCC浸润、转移和预后的关系。结果:CD44v6和MMP-9在LSCC组织中均过度表达。CD44v6表达与LSCC病理分化程度、颈淋巴结转移及术后5年生存率有关(均P<0.05);MMP-9表达与LSCC颈淋巴结转移、临床分期及T分期有关(均P<0.05)。LSCC组织中CD44v6和MMP-9的表达呈显著正相关(均P<0.01)。结论:LSCC组织中CD44v6和MMP-9的表达密切相关。CD44v6和MMP-9的表达可作为临床上判断LSCC浸润、淋巴结转移及评估预后的客观指标。
Objective: To investigate the expression of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma (LSCC) and its clinical significance. Methods: The expressions of CD44v6 and MMP-9 in 27 cases of LSCC and 8 cases of normal laryngeal mucosa tissues were detected by immunohistochemical SABC method. The relationship between the expressions of CD44v6 and MMP-9 and the infiltration, metastasis and prognosis of LSCC was analyzed. Results: CD44v6 and MMP-9 were overexpressed in LSCC tissues. The expression of CD44v6 correlated with the degree of pathological differentiation, cervical lymph node metastasis and 5-year survival rate of LSCC (all P <0.05). The expression of MMP-9 was correlated with cervical lymph node metastasis, clinical stage and T stage (all P <0.05). The expressions of CD44v6 and MMP-9 in LSCC were positively correlated (all P <0.01). Conclusion: The expressions of CD44v6 and MMP-9 in LSCC are closely related. The expression of CD44v6 and MMP-9 can be used as objective indicators to judge the infiltration of LSCC, lymph node metastasis and prognosis in clinic.