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Identifying the problem regions and regional problems, and thus improving regional policies, are crucial for the sustainable development of various economic entities. The coordinated development of industrialization, informatization, urbanization and agricultural modernization(hereinafter referred to as "Sihua") is not only a practical need but an important strategic direction of integrating urban-rural development and regional development in recent China, and it also provides a significant perspective for identifying problem regions and regional problems so as to improve the regional policies. This study mainly aims to: firstly, establish a comprehensive evaluation index system so as to explore the spatial pattern of coordinated development of Sihua in China at prefecture level; secondly, to develop an evaluation criteria system to identify the problem regions and regional problems from the perspective of coordinated development of Sihua. This paper comes first in the scientific community to evaluate the coordinated development state of Sihua in China at prefecture level and identify the problem regions and regional problems from the perspective of Sihua development by quantitative analysis. This study may benefit the improvement of regional policies and thus contribute to the sustainable socio-economic development of China.