目的:探讨白癜风患者效应性T细胞(Teff)、调节性T细胞(Treg)及其细胞因子表达情况及临床意义。方法:选取2018年6月至2019年6月期间德州市人民医院皮肤性病科收治的白癜风患者84例(稳定期38例，进展期46例)及健康体检者30例(对照组)为研究对象，采用流式细胞实验检测受试者外周血Teff亚群、Treg细胞水平，采用酶联免疫吸附法检测Teff亚群、Treg细胞相关细胞因子水平，分析外周血Teff亚群与Treg细胞水平间关系，Teff亚群、Treg细胞相关细胞因子与白癜风病程、皮损面积关系。结果:白癜风组外周血Th17、Th22水平较对照组明显升高，Treg细胞水平明显降低(n P<0.05)；与白癜风稳定组比较，白癜风进展组外周血Th17、Th22水平升高，Treg细胞水平降低(n P<0.05)；Treg细胞与Th17细胞水平呈负相关(n r＝-0.303，n P＝0.001)，与Th22细胞水平呈负相关(n r＝-0.200，n P＝0.033)；白癜风组血清IL-17、IL-22水平较对照组明显升高，TGF-β水平明显降低(n P<0.05)；与白癜风稳定组比较，进展组血清IL-17、IL-22水平升高，TGF-β水平降低(n P<0.05)。白癜风患者血清IL-17水平与皮损面积呈正相关(n r＝0.361，n P<0.05)，IL-22水平与皮损面积呈正相关(n r＝0.288，n P<0.05)，TGF-β水平与皮损面积呈负相关(n r＝-0.312，n P<0.05)。n 结论:白癜风患者存在Teff/Treg细胞失衡，明显向Teff亚群偏移，白癜风疾病进展可能与Teff亚群、Treg细胞相关细胞因子有关。“,”Objective:To investigate the expression and clinical significance of effector T cell (Teff), regulatory T cell (Treg) and their cytokines in patients with vitiligo.Methods:84 patients with vitiligo (38 cases in stable stage, 46 cases in advanced stage) who were admitted to the Dermatology Department of the Dezhou People's Hospital between June 2018 and June 2019 and 30 healthy people (control group) were enrolled in the study. The levels of Teff subsets and Treg cells in peripheral blood were detected by flow cytometry. The levels of Teff subsets and Treg cells-associated cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The relationship between Teff subsets and Treg cells levels in peripheral blood, relationship between Teff subgroups, Treg cells-associated cytokines and course of vitiligo, skin lesion area were analyzed.Results:The levels of T helper cell (Th)17 and Th22 in peripheral blood of vitiligo group were significantly higher than those of control group, while levels of Treg cells were significantly lower than control group (n P<0.05). Compared with the stable vitiligo group, the levels of Th17 and Th22 in peripheral blood were higher and levels of Treg cells were lower in the advanced vitiligo group (n P<0.05). Treg cell level was negatively correlated with Th17 cell level (n r=-0.303, n P=0.001), and negatively correlated with Th22 cell level (n r=-0.200, n P=0.033). The levels of serum interleukin (IL)-17 and IL-22 in vitiligo group were significantly higher than those in control group, while the level of transforming growth factor-β (TGF-β) was significantly lower than that in control group (n P<0.05). Compared with the stable vitiligo group, levels of serum IL-17 and IL-22 were higher and level of TGF-β was lower in the advanced vitiligo group (n P<0.05). Correlation analysis showed that levels of IL-17 and IL-22 were positively correlated with skin lesion area (n r=0.361, 0.288, n P<0.05), and level of TGF-β was negatively correlated with skin lesion area (n r=-0.312, n P<0.05).n Conclusions:Teff/Treg cells are unbalanced in patients with vitiligo, showing obvious shift to Teff subsets. The progression of vitiligo may be related to Teff subsets and Treg cells-associated cytokines.