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PP2A是一种丝 /苏氨酸磷蛋白磷酸酶 ,通过可逆性磷酸化使已磷酸化激活的蛋白质脱磷酸 ,在信号传导中承担负性调节的作用。由一个催化亚基和两个调节亚基构成。PP2A是一种多功能性酶 ,底物为众多体内的转录因子和蛋白激酶 ;酵母 ,果蝇和小鼠的动物模型的研究中已经发现PP2A在细胞周期调控 ,形态以及发育中的作用 ;同时它又在信号转导的级联反应中与其他磷酸化酶和激酶相互作用 ,构成调节大分子调控下游信号的转导。催化亚基活性主要由转录后水平磷酸化和甲基化的状态调控
PP2A is a filamentous / threonine phosphoprotein phosphatase that dephosphorylates phosphorylated activated proteins through reversible phosphorylation, which plays a negative regulatory role in signal transduction. Consists of a catalytic subunit and two regulatory subunits. PP2A is a versatile enzyme that targets a wide range of in vivo transcription factors and protein kinases; the role of PP2A in cell cycle regulation, morphology, and development has been found in animal models of yeast, Drosophila and mice It in turn interacts with other phosphorylases and kinases in a cascade of signal transduction to form the transduction that regulates downstream signals that regulate macromolecules. The catalytic subunit activity is mainly regulated by the post-transcriptional phosphorylation and methylation status