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研究了一种氧化白藜芦醇的简便合成方法.以廉价易得的3,5-二羟基苯乙酮(1)为原料,经甲基化及Willgerodt-Kindler重排反应得到3,5-二甲氧基苯乙酸(3),3,5-二甲氧基苯乙酸(3)与2,4-二甲氧基苯甲醛(4)经Perkin反应构建二苯乙烯骨架,再经脱羧及脱甲基异构化反应得到目标产物氧化白藜芦醇(7),总收率为30%.在合成过程中,各步产物收率高、反应条件温和、操作简便,各中间体及产物结构经MS,IR,1HNMR及13CNMR确证.
A simple and convenient method for the synthesis of oxidized resveratrol was studied. 3,5-Dihydroxyacetophenone (1), which is cheap and readily available, was used as a starting material to give 3,5- (3), 3,5-dimethoxyphenylacetic acid (3) and 2,4-dimethoxybenzaldehyde (4) by Perkin reaction to construct the stilbene skeleton, and then by decarboxylation and Demethylation of the target product afforded the target product of resveratrol (7), the total yield of 30% .In the synthesis process, the yield of each step is high, the reaction conditions are mild, easy to operate, the intermediates and products Structure confirmed by MS, IR, 1HNMR and 13CNMR.