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目的观察缬沙坦与小剂量双氢克尿噻联合治疗高血压病的疗效及其对代谢的影响。方法84例轻中度原发性高血压患者随机分为2组,缬沙坦组:缬沙坦80～160mg,1次/d,口服;缬沙坦联合双氢克尿噻组:缬沙坦80mg+双氢克尿噻12.5mg,1次/d,口服。2组均治疗8周,治疗前后测基础血压、血脂、空腹血糖、血尿酸、血肌酐、血钾。结果缬沙坦联合小剂量双氢克尿噻组较单用缬沙坦组降压总有效率明显提高(P<0.01),2组治疗前后代谢指标无明显变化,2组均无明显不良反应。结论缬沙坦联合小剂量双氢克尿噻治疗轻中度原发性高血压病优于单用缬沙坦。
Objective To observe the effect of valsartan combined with low-dose hydrochlorothiazide in the treatment of hypertension and its effect on metabolism. Methods Eighty-four patients with mild-to-moderate essential hypertension were randomly divided into 2 groups: valsartan group: valsartan 80 ~ 160 mg once daily, valsartan combined with hydrochlorothiazide group: valsartan Tan 80mg + hydrochlorothiazide 12.5mg, 1 / d, orally. The two groups were treated for 8 weeks. Baseline blood pressure, blood lipid, fasting blood glucose, serum uric acid, serum creatinine and serum potassium were measured before and after treatment. Results The total effective rate of valsartan combined with low-dose hydrochlorothiazide group was significantly higher than that of valsartan group alone (P <0.01). There was no significant difference in metabolic index between the two groups before and after treatment, and no significant adverse reactions . Conclusion Valsartan combined with low-dose hydrochlorothiazide treatment of mild to moderate essential hypertension is better than valsartan alone.