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目的探讨血清脂联素(adiponectin,APN)水平与冠状动脉粥样硬化性心脏病(CHD)之间的关系。方法应用酶联免疫法(ELISA)测定了21例急性心肌梗死(AMI)、31例不稳定型心绞痛(UAP)、13例稳定型心绞痛(SAP)患者和21例正常对照组的血清APN水平。所有患者与正常对照组均已行冠状动脉造影术。分别与对照组比较各组APN、受累血管病变积分、BMI、Cho、Tg、HDL-c及FBG水平。结果①CHD组血清APN水平显著低于对照组(P<0.01)。②SAP组、UAP组和AMI组血清APN水平明显低于对照组(P<0.01),且依次下降,但三组间差异无统计学意义。结论 CHD患者血清APN水平显著下降,低水平的APN水平可能与CHD的发生与发展有关。
Objective To investigate the relationship between serum adiponectin (APN) and coronary atherosclerotic heart disease (CHD). Methods Serum levels of APN in 21 AMI patients, 31 unstable angina pectoris (UAP) patients, 13 stable angina pectoris (SAP) patients and 21 normal controls were measured by enzyme - linked immunosorbent assay (ELISA). Coronary angiography was performed in all patients and normal controls. The levels of APN, vascular involvement, BMI, Cho, Tg, HDL-c and FBG in each group were compared with those in control group. Results ① The level of serum APN in CHD group was significantly lower than that in control group (P <0.01). ② Serum APN levels in SAP group, UAP group and AMI group were significantly lower than those in control group (P <0.01), and decreased in turn, but there was no significant difference among the three groups. Conclusions Serum levels of APN are significantly decreased in patients with CHD, and low levels of APN may be related to the occurrence and development of CHD.