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梔子花为我国民间避孕草药。经乙酸乙酯提取,硅酸层析等处理,得到一个酸性部位,简称 E-97。给大白鼠和狗皮下注射39和5克生药/公斤,连续3天;对大白鼠及家兔十二指肠每天给 E-97生药30克/公斤,连续3天,均可产生明显的抗早孕作用。如给大白鼠灌服39克生药/公斤,连续3天,则不能抗早孕。E-97对豚鼠无异常的过敏性反应。对家兔股四头肌刺激性的试验为轻微反应。每天给猕猴口服75克生药1公斤,连续2—3周,其血象、肝功能、肾功能和体内主要脏器均未见明显的病理变化。
Gardenia flowers for our civilian contraceptive herbs. Ethyl acetate extraction, silicic acid chromatography and other processing, to obtain an acidic site, referred to as E-97. Rats and dogs were subcutaneously injected with 39 and 5 g of crude drug per kilogram for 3 consecutive days. E-97 crude drug (30 g / kg) was given daily to the duodenum of rats and rabbits for 3 consecutive days. Early pregnancy effect. If rats fed 39 grams of crude drug / kg, for 3 days, you can not anti-pregnancy. E-97 has no abnormal allergic reaction to guinea pigs. Stimulation of rabbit quadriceps muscle test is a slight reaction. Rhesus monkeys a day oral administration of 75 grams of crude drugs 1 kg for 2-3 weeks, the blood, liver function, renal function and major organs in vivo no significant pathological changes.