以线性推动力模型为基础,建立考虑轴向扩散、传质阻力和非线性吸附的色谱分离动力学模型,得到一组偏微分方程, 然后用线上求解法将偏微分方程转化为常微分方程,采用MATLAB的常微分方程求解器求解。部分模拟结果与试验值进行了比较,结果表明,线上求解法结合MATLAB的常微分求解器可快速、准确地模拟色谱分离过程。 Based on the linear driving force model, a kinetic model of chromatographic separation considering axial diffusion, mass transfer resistance and non-linear adsorption was established to obtain a set of partial differential equations. Then the partial differential equations were transformed into the ordinary differential equations , Using ordinary differential equation solver MATLAB solution. Some simulation results and experimental values ​​are compared. The results show that the online solution combined with MATLAB’s ordinary differential solver can simulate the chromatographic separation process quickly and accurately.