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目的 研究老年慢性阻塞性肺疾病 (COPD)急性发作期患者的营养状态和脂类代谢的变化和相互关系。方法 通过人体测量和内脏蛋白测定对 53例 COPD合并呼吸道感染的老年住院患者进行营养评价 ,应用气相色谱法测定血清游离脂肪酸 ,常规方法测定脂类与脂蛋白。结果 营养正常者 (A组 )占 30 2 % ,营养不良者 (B组 )占 69 8% ,两组患者血清甘油三酯 ,总游离脂肪酸均明显下降 (P<0 0 5～ <0 0 1 ) ,其中以亚油酸、亚麻酸等必需脂肪酸降低显著 (P<0 0 1 )。结论 老年 COPD急性发作期患者多伴有甘油三酯和必需脂肪酸缺乏 ,后者可能是加剧 COPD病情恶化的因素之一。
Objective To study the changes and correlations of nutritional status and lipid metabolism in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Fifty-three elderly hospitalized patients with COPD and respiratory tract infections were evaluated for nutritional status by human body measurements and visceral protein assay. Serum free fatty acids were determined by gas chromatography and lipids and lipoproteins were determined by routine methods. Results Serum triglyceride and total free fatty acid were significantly decreased in both groups (P <0.05 ~ <0.01 ), Among which the essential fatty acids such as linoleic acid and linolenic acid decreased significantly (P <0.01). Conclusion The elderly patients with acute exacerbation of COPD often accompanied by triglyceride and essential fatty acid deficiency, the latter may aggravate the exacerbation of COPD one of the factors.