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目的 探讨血清血管内皮细胞生长因子 (VEGF)与系统性硬化病 (SSc)肺间质病变的关系。方法 采用免疫学酶联免疫吸附测定 (ELISA)方法检测了病例组 (SSc 2 0例 )及正常对照组( 3 0名 )的血清VEGF ,并分析血清VEGF与肺功能的关系。结果 病例组血清VEGF ( 3 63± 178)ng/L较正常对照组 ( 183± 5 9)ng/L明显升高 (P <0 0 0 1) ,VEGF升高的SSc患者肺间质病变的发生率 ( 87 5 % )显著高于VEGF正常的SSc病患者肺间质病的发生率 ( 3 3 3 % ) (P <0 0 5 ) ,SSc患者血清VEGF浓度与肺活量占预计值百分比 (VC % )及肺一氧化碳弥散量占预计值百分比 (DLCO % )呈负相关 (r =- 0 86,P <0 0 0 1;r =- 0 87,P <0 0 0 1)。结论 血清VEGF水平的测定 ,对评估SSc肺间质病变的病情活动性有意义
Objective To investigate the relationship between serum vascular endothelial growth factor (VEGF) and interstitial lung disease (SSc) in patients with systemic sclerosis (SSc). Methods The serum levels of VEGF in 20 cases of SSc and 30 cases of normal controls were detected by ELISA, and the relationship between serum VEGF and pulmonary function was analyzed. Results The serum levels of VEGF (3 63 ± 178) ng / L in the case group were significantly higher than those in the normal control group (183 ± 59 ng / L) (P 0 01 0). The levels of VEGF in SSc patients with interstitial lung disease (87.5%) was significantly higher than that of SSc patients with normal VEGF (33.3%) (P <0.05). The serum levels of VEGF and the percentage of vital capacity in the SSc patients (VC %), And the proportion of diffusing carbon monoxide in the lung as a percentage of expected value (DLCO%) (r = - 0 86, P <0.01 1; r = - 0 87, P 0 01). Conclusion The determination of serum VEGF level is of great significance in assessing the disease activity of SSc interstitial lung disease