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复发性阿弗他溃疡(recurrent aphthous ulcer,RAU)是口腔黏膜最常见的疾病之一,但其病因及致病机制仍不明,近年对RAU的研究多集中在免疫失调方面,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)作为细胞因子的一员在RAU的发生和发展中起着重要的作用。研究表明TNF-α在RAU中表达升高,并证明TNF-α的高表达可引起细胞因子网络的失衡,并对细胞毒性作用有一定的影响;另外,TNF-α还可以过作用于黏附分子而促进炎细胞向病变组织的移行。所以TNF-α在RAU炎症反应的发生和溃疡病损的形成中起着起着重要的作用。
Recurrent aphthous ulcer (RAU) is one of the most common oral mucosal diseases, but its etiology and pathogenesis remain unclear. In recent years, the research on RAU has focused on immune disorders. Tumor necrosis factor-alpha Tumor necrosis factor-α (TNF-α), as a member of cytokines, plays an important role in the occurrence and development of RAU. Studies have shown that elevated TNF-α expression in RAU, and that TNF-α high expression can cause cytokine network imbalance and cytotoxicity have a certain impact; In addition, TNF-α can also be over-acting on adhesion molecules And promote the migration of inflammatory cells to diseased tissue. Therefore, TNF-α plays an important role in the occurrence of RAU inflammation and the formation of ulcer lesions.