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目的:观察低强度运动对大鼠焦虑情绪和海马CA1区局部场电位theta节律活动的影响。方法:将雄性Wistar大鼠随机分为对照组(control group,CG)和运动组(exercise group,EG),其中CG不进行运动,EG大鼠进行为期4周的低强度跑台运动。此后进行旷场实验,检测大鼠焦虑情绪的变化。行为学实验结束后,采用在体多通道局部场电位电生理记录技术,分析大鼠海马CA1区theta节律的改变。结果:在旷场实验中,与CG相比,EG大鼠在中央区域停留时间和活动距离均显著增加(P<0.05);同时,EG大鼠海马CA1区由夹尾刺激诱导的局部场电位theta节律的功率峰值较CG大鼠明显降低(P<0.05),而theta节律功率峰值对应的频率不存在明显的组间差异(P>0.05)。结论:低强度运动可使大鼠焦虑情绪降低,探索行为活跃并导致海马theta节律功率压抑。这提示,低强度运动所引起的情绪变化可能与海马theta节律的功率峰值降低有关,海马局部场电位theta节律的改变可能是运动改善焦虑情绪的神经调控机制之一。
AIM: To observe the effects of low-intensity exercise on anxiety and theta rhythmicity in rat hippocampal CA1 region. Methods: Male Wistar rats were randomly divided into control group (CG) and exercise group (EG), in which CG was not exercised and EG rats were given low intensity treadmill exercise for 4 weeks. Afterwards, the open field experiment was conducted to detect the change of anxiety in rats. Behavioral experiments after the end of the use of multi-channel local field potential electrophysiological recording technology to analyze changes in theta rhythm in rat hippocampal CA1 area. RESULTS: In the open-field test, the residence time and distance traveled in the central area of EG rats were significantly increased compared with CG rats (P <0.05). Meanwhile, the local field potentials induced by pinch-tail stimulation Theta rhythm power peak was significantly lower than CG rats (P <0.05), while theta rhythm power peak frequency corresponding to no significant difference between groups (P> 0.05). Conclusion: Low-intensity exercise can reduce anxiety, explore behavior and lead to depression of theta rhythm in the hippocampus. This suggests that the mood changes induced by low-intensity exercise may be related to the decrease of the power peak of theta rhythm in the hippocampus. The change of theta rhythms in the hippocampus may be one of the mechanisms of neural regulation of anxiety-improving exercise.