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目的研究小鼠醋氨酚（Ａｃｅ）的有关药代动力学及苯巴比妥钠（Ｐｈｅ）对其的影响。方法给正常小鼠和Ｐｈｅ５０ｍｇ·ｋｇ－１ｉｐ７ｄ的小鼠，尾静脉注射Ａｃｅ１００ｍｇ·ｋｇ－１，用ＨＰＬＣ法测定血浆Ａｃｅ及尿液Ａｃｅ、葡萄糖醛酸—Ａｃｅ（ＧＡ）和硫酸—Ａｃｅ（ＳＡ）含量，计算机自动曲线拟合，计算比较其有关药代动力学参数及尿液代谢产物累积排泄量。结果小鼠Ａｃｅ血浆浓度量－时关系曲线呈一房室模型，Ｔ１２为１３．９±０．５５ｍｉｎ，ＣＬ为（０．０４０３２±０．００３８２）Ｌ·ｋｇ－１·ｍｉｎ－１，９ｈ尿液Ａｃｅ、ＧＡ和ＳＡ总累积排泄量为给药量的５４．０％±６．２１％。经Ｐｈｅ诱导后，ＡｃｅＴ１２缩短２７．７％，ＣＬ增加２５．２％，尿液ＧＡ减少１９．３％（Ｐ＜０．０５）。结论至少在ＩＣＲ和昆明种小鼠，Ａｃｅ除与葡萄糖醛酸和硫酸结合外，还有其它重要代谢途径。Ｐｈｅ预处理明显加快小鼠血浆Ａｃｅ消除，但该作用与葡萄糖醛酸和硫酸结合代谢反应无关。
Objective To study the pharmacokinetics of acetaminophen (Ace) in mice and the effect of phenobarbital sodium (Phe) on it. Methods Acetylcholine (100mg · kg-1) was injected into the tail vein of normal mice and mice with Phe50mg · kg-1ip7d. Acetone, urine Ace, glucuronic acid-Ace and sulfuric acid- Content, computer automatic curve fitting, calculation and comparison of its pharmacokinetic parameters and cumulative urinary metabolites excretion. Results The plasma concentration-time curve of mouse Ace showed a one-compartment model with T12 of 13.9 ± 0.55 min and CL of (0.04032 ± 0.00382) L · kg-1 · min-1 and 9 h urine The total cumulative excretion of liquid Ace, GA and SA was 54.0% ± 6.21% of the dose. After Phe induction, AceT12 shortened by 27.7%, CL increased by 25.2% and urine GA decreased by 19.3% (P <0.05). Conclusions In addition to glucocorticoids and sulfuric acid, Ace has other important metabolic pathways, at least in ICR and Kunming mice. Phe pretreatment significantly accelerated the elimination of Ace plasma in mice, but the effect was not related to the metabolic reaction of glucuronic acid and sulfate.