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目的探讨鼻咽癌(NPC)患者血浆骨桥蛋白(OPN)检测的临床意义。方法采用酶联免疫吸附试验检测44例NPC患者和32例健康体检者的血浆OPN,分析NPC患者血浆OPN水平和NPC各病理特征的关系。结果 NPC组血浆OPN水平显著高于对照组,差异有统计学意义[(146.9±42.0)ng/mlvs.(37.1±8.2)ng/ml,P=0.000];TNM分期中N1～3期OPN水平显著高于N0期(P=0.000),临床分期中Ⅲ～Ⅳ期OPN水平高于Ⅰ～Ⅱ期(P=0.000),T3+4期和T1+2期的OPN水平无统计学差异(P=0.968),病理分期中低分化和中、高分化OPN水平之间差异无统计学意义(P=0.914)。OPN水平在性别、年龄之间并无关联性(P=0.220,P=0.936),OPN水平与T期、病理分期无相关性(r=0.072,P=0.642;r=0.014,P=0.930),OPN水平与N期、临床分期呈正相关(r=0.764,P=0.000;r=0.812,P=0.000)。结论血浆OPN水平可作为评判NPC病程和预后的较好的血清学指标。
Objective To investigate the clinical significance of detecting plasma osteopontin (OPN) in patients with nasopharyngeal carcinoma (NPC). Methods Serum OPN was detected by enzyme-linked immunosorbent assay in 44 NPC patients and 32 healthy subjects, and the relationship between plasma OPN levels and NPC pathological features was analyzed. Results The level of OPN in NPC group was significantly higher than that in control group [(146.9 ± 42.0) ng / ml vs (37.1 ± 8.2) ng / ml, P = 0.000] (P = 0.000). The level of OPN in stage Ⅲ ~ Ⅳ was higher than that in stage Ⅰ ~ Ⅱ (P = 0.000), while the level of OPN in stage T3 + 4 and T1 + 2 was no significant difference (P = 0.968). There was no significant difference between poorly differentiated and well-differentiated OPN in pathological stage (P = 0.914). No correlation was found between OPN level and T stage and pathological stage (r = 0.072, P = 0.642; r = 0.014, P = 0.930) There was a positive correlation between OPN level and N stage and clinical stage (r = 0.764, P = 0.000; r = 0.812, P = 0.000). Conclusions Plasma OPN levels can be used as a good serological index to judge the course and prognosis of NPC.