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目的 :探讨细胞凋亡调节基因蛋白表达与前列腺癌临床预后的关系。方法 :采用免疫组化染色方法 ,检测 5 7例前列腺癌中Fas及其配体 (FasL)、bcl 2、bax的表达 ,并同前列腺癌临床和病理特征一起 ,先后进行单因素和多因素分析。结果 :bax在前列腺癌低分化肿瘤中的表达强于在高分化肿瘤中的表达 (P <0 0 5 ) ;FasL表达可能对生存预后有一定影响 ,而肿瘤分化程度与临床分期仍是重要的预后指标。结论 :FasL表达可能与前列腺癌预后有关。
Objective: To investigate the relationship between the expression of apoptosis-regulating gene and the clinical prognosis of prostate cancer. Methods: Immunohistochemical staining was used to detect the expression of Fas and its ligands (FasL), bcl 2 and bax in 57 cases of prostate cancer. The clinical and pathological features of prostate cancer were analyzed by univariate and multivariate analysis . Results: The expression of bax in poorly differentiated prostate cancer tissues was stronger than that in well differentiated tumors (P <0.05). The expression of FasL may have an impact on the prognosis of the patients, but the degree of tumor differentiation and clinical stage were still significant Prognosis index. Conclusion: FasL expression may be related to the prognosis of prostate cancer.