论文部分内容阅读
目的 探讨散发严重急性呼吸综合征(SARS)患者实验室检查的特点。方法 分析 2004年确诊 4例散发SARS患者的实验室检查结果。结果 白细胞及淋巴细胞呈不同程度降低,下降时间较流行时提早,下降程度较小。2例外周血T淋巴细胞亚群计数轻微降低。3例丙氨酸氨基转移酶 (ALT)和天冬氨酸氨基转移酶(AST)轻度升高。肾功能、血糖、血脂及心肌酶无异常。血氧饱和度均无降低。所有病人血清SARS IgM/G抗体早在发病第 6天由阴转阳,滴度在短期内呈 4倍以上升高,中和抗体实验阳性, 1例咽拭子中检测出SARS CoVRNA。结论 2004年中国 4例散发病例,临床表现较轻,病程短,无并发症,归因于此次致病的SARS CoV毒力小,抗体出现较早,病毒迅速被清除。
Objective To investigate the characteristics of laboratory tests in patients with severe acute respiratory syndrome (SARS). Methods The laboratory results of 4 SARS cases diagnosed in 2004 were analyzed. Results Leukocytes and lymphocytes decreased to different extents, the descending time was earlier than that of epidemic, and the decrease was less. 2 cases of peripheral blood T lymphocyte subsets count slightly lower. Three cases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased slightly. Renal function, blood glucose, lipids and myocardial enzymes were normal. No decrease in oxygen saturation. Serum SARS IgM / G antibody of all patients returned from yin to yang on the 6th day of onset, the titer increased more than 4 times within a short period of time, the neutralizing antibody test was positive, SARS CoVRNA was detected in 1 case of throat swab. CONCLUSIONS: Four cases of sporadic cases in China in 2004 showed mild clinical manifestations, short course of disease and no complication. Due to the low virulence of the pathogenic SARS CoV, the antibody appeared earlier and the virus was rapidly eliminated.