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肝纤维化是一种常见的慢性进行性疾病,是肝脏对各种急、慢性损伤产生的一种“创伤-修复”的病理过程,同时也是多种慢性肝病发展到肝硬化甚至肝癌的必经阶段。目前认为,肝星状细胞(hepatic stellate cell,HSC)的激活、增殖及细胞外基质(extracellularmatrixc,ECM)的过度沉积是肝纤维化发生的重要环节。多种细胞因子参与了肝纤维化的启动和持续发展,其中转化生长因子β1(TGF-β1)是体内最强且最广泛的促纤维化介质之一,其能激活HSC,促进表达ECM,是肝纤维化首要的调控因子,TCF-β1的信号转导与调
Liver fibrosis is a common chronic progressive disease. It is a “trauma-repair” pathological process that the liver produces for various acute and chronic injuries. It is also a variety of chronic liver diseases that develop into cirrhosis and even liver cancer Must pass the stage. At present, it is thought that the activation and proliferation of hepatic stellate cells (HSC) and the excessive deposition of extracellular matrix (ECM) are important links in the development of hepatic fibrosis. A variety of cytokines are involved in the initiation and continuous development of hepatic fibrosis. Among them, transforming growth factor β1 (TGF-β1) is one of the strongest and most extensive fibrotic mediators in the body, which can activate HSC and promote the expression of ECM Regulatory factor of liver fibrosis, TCF-β1 signal transduction and regulation