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目的研究老年肺结核患者采用抗肺结核药物治疗的效果。方法在2015年9月~2016年10月收治的老年肺结核患者中选出60例为本次研究的对象,根据治疗方法差异分组,对照组患者给予标准抗结核方案治疗(乙胺丁醇+异烟肼+比嗪酰胺+利福平),观察组患者给予改进抗结核方案治疗(乙胺丁醇+异烟肼+比嗪酰胺+利福喷丁),对比两组患者的治疗效果指标。结果观察组患者的治疗总有效率比对照组高,且治疗后的血清AST、ALT水平低于对照组患者,P<0.05;观察组患者的不良反应发生率10.0%低于对照组的33.33%,P<0.05。结论含利福喷丁的抗肺结核方案治疗老年肺结核是安全有效的,不良反应少,对患者肝功能的损害较小,有助于提高患者生命质量,且用药方法简单,值得推广。
Objective To study the effect of anti-tuberculosis drug treatment in elderly patients with pulmonary tuberculosis. Methods 60 elderly patients with pulmonary tuberculosis who were admitted to our hospital from September 2015 to October 2016 were selected as the subjects of this study. Patients in the control group were treated with standard anti-TB regimen (ethambutol + The patients in the observation group were treated with modified anti-TB regimen (ethambutol + isoniazid + biotinamide + rifapentine), and the therapeutic effect was compared between the two groups. Results The total effective rate of observation group was higher than that of control group, and the serum AST and ALT levels after treatment were lower than those of control group (P <0.05). The incidence of adverse reactions in observation group was 10.0% lower than that of control group (33.33% , P <0.05. Conclusions The anti-tuberculosis regimen containing rifapentin is safe and effective in the treatment of elderly pulmonary tuberculosis with less adverse reactions and less damage to liver function. It is helpful to improve patients’ quality of life and is simple to treat. It is worthy of promotion.