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目的 :观察海藻消瘿颗粒对小鼠甲状腺吸 1 2 5 I率及尿中 1 2 5 I排出量的影响。方法 :给药组动物每日分别灌服海藻消瘿颗粒 (1.0 14g/ kg、3.0 42 g/ kg、5 .0 7g/ kg)连续 10 d。末次给药后 1h给动物腹腔注射 1 2 5 I0 .314uci/ 10 g体重后 ,分别将动物置代谢笼 ,收集 2 4h尿液 ,供尿 1 2 5 I排出量试验用。随后分别于 2 h、6 h、2 4h、48h处死动物 ,剥离、摘出整个甲状腺 ,放免法测甲状腺吸 1 2 5 I率 ,观察药物的作用。结果 :海藻消瘿颗粒可使甲状腺吸 1 2 5 I率降低 ,同时吸 1 2 5 I率高峰推迟。结论 :海藻消瘿颗粒具有一定的抑制甲状腺功能作用 ,为临床应用及新药开发提供了一定的依据。
Objective : To observe the effect of Haiza Xiaoxiao Granule on the rate of thyroid uptake in mice and the amount of urinary 125I excretion. Methods: Animals in the treatment group were fed with seaweed Xiaoyu granules (1.0 14g/kg, 3.042 g/kg, 5.07g/kg) for 10 days. At 1h after the last administration, animals were intraperitoneally injected with 1 2 5 I0.314uci/10 g body weight, and the animals were placed in a metabolic cage to collect 24 hours of urine for urinary I 2 I I excretion test. Subsequently, animals were sacrificed at 2 h, 6 h, 24 h, and 48 h respectively. The entire thyroid gland was dissected and removed. The rate of thyroid uptake was measured by radioimmunoassay and the effect of the drug was observed. Results : The algae Xiaoyu granules could reduce the rate of thyroid uptake and the peak rate of smoking 1 2 5 I was postponed. Conclusion : The seaweed Xiaopi granules have a certain role in inhibiting thyroid function, providing a certain basis for clinical application and development of new drugs.