目的研究观察倍他洛克联用奥美拉唑治疗肝炎后肝硬化合并消化性溃疡的疗效。方法 74例肝炎后肝硬化合并消化性溃疡患者,按照数字标号随机分为对照组和观察组,各37例。对照组实施常规保肝抗纤维化用药,再行阿莫西林与克拉霉素用药治疗,观察组实施倍他洛克联用奥美拉唑治疗,对比两组疗效。结果观察组患者总有效率为97.30%,显著高于对照组的78.38%,差异具有统计学意义(P<0.05)。观察组患者在用药治疗期间未出现消化道出血症状,仅2例伴有呕吐,1例恶心感,1例心动过速;而对照组患者在用药治疗期间发生5例消化道出血,且1例大出血症状,观察组消化道出血情况少于对照组,差异有统计学意义(P<0.05)。结论倍他洛克联用奥美拉唑治疗肝炎后肝硬化合并消化性溃疡疗效确切,用药安全性高,值得临床推广应用。 Objective To study the efficacy of metoprolol combined with omeprazole in the treatment of posthepatitic cirrhosis and peptic ulcer. Methods A total of 74 patients with posthepatitic cirrhosis complicated with peptic ulcer were randomly divided into control group and observation group according to the numbers. Control group to implement conventional anti-liver fibrosis drugs, followed by amoxicillin and clarithromycin treatment, observation group implementation of beta Lotto combined with omeprazole treatment, the two groups were compared. Results The total effective rate of observation group was 97.30%, which was significantly higher than that of control group (78.38%), the difference was statistically significant (P <0.05). In the observation group, there were no symptoms of gastrointestinal bleeding during the course of medication, only two cases had vomiting, one case had nausea and one case had tachycardia. In the control group, five cases of gastrointestinal bleeding occurred during the course of medication and one case Bleeding symptoms, the observation group gastrointestinal bleeding less than the control group, the difference was statistically significant (P <0.05). Conclusions Betaloc and Omeprazole combined with omeprazole in the treatment of posthepatitic cirrhosis complicated with peptic ulcer are effective and safe. It is worthy of clinical application.