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目的 研究局部动脉内灌注重组链激酶（rSK）治疗急性脑梗死的疗效。方法7例急性脑梗死患者,其中大脑中动脉闭塞4例,基底动脉闭塞1例,颈内动脉闭塞2例。从发病到开始治疗的时间为0.5～16h,局部动脉内灌注rSK30万～100万IU。第7d及第90d后作临床疗效评定。结果 完全再通5例,部分再通1例,术中发生再栓塞1例。完全再通的5例,rSK平均用量61万IU,平均再通时间63min。1例并发颅内血肿,1例出现大面积梗死。90d后基本痊愈4例,显著进步1例,进步2例。结论 局部动脉内灌注rSK能有效溶解脑血栓,疗效良好。
Objective To study the curative effect of local intra-arterial infusion of recombinant streptokinase (rSK) on acute cerebral infarction. Methods Seven patients with acute cerebral infarction, including middle cerebral artery occlusion in 4 cases, basilar artery occlusion in 1 case and internal carotid artery occlusion in 2 cases. From the onset to the beginning of treatment for 0.5 ~ 16h, local arterial perfusion rSK 300000 ~ 1 million IU. 7d and 90d after the clinical efficacy evaluation. Results completely recanalization in 5 cases, partial recanalization in 1 case, intraoperative embolization occurred in 1 case. Complete recanalization in 5 cases, rSK average dosage of 610000 IU, the average recanalization time 63min. One patient had complicated intracranial hematoma and one patient had large infarction. After 90 days, 4 cases were basically cured, 1 case improved significantly and 2 cases improved. Conclusion Local intra-arterial infusion of rSK can effectively dissolve cerebral thrombosis and has good curative effect.