论文部分内容阅读
目的:探讨了鼻咽癌患者放疗前后血清TNF-α、β2-m水平的变化及临床意义。方法:应用放射免疫分析对31例鼻咽癌患者进行了血清TNF-α、β2-m水平测定,并与35名正常健康人作比较。结果:鼻咽癌患者在放疗前血清TNF-α、β2-m水平非常显著地高于正常人组(P<0.01),放疗后三个月则与正常人比较无显著性差异(P>0.05)。结论:测定鼻咽癌患者血清中TNF-α、β2-m水平的变化对临床疗效观察和预后判断均有重要的临床意义。
Objective: To investigate the changes and clinical significance of serum TNF-α and β2-m levels in patients with nasopharyngeal carcinoma before and after radiotherapy. METHODS: Serum TNF-α and β2-m levels were measured in 31 patients with nasopharyngeal carcinoma by radioimmunoassay and compared with 35 normal healthy subjects. Results: Serum levels of TNF-α and β2-m in patients with nasopharyngeal carcinoma before radiotherapy were significantly higher than those in the normal group (P<0.01), and there was no significant difference between the two groups after radiotherapy (P>0.05). ). Conclusion: The determination of serum TNF-α and β2-m levels in nasopharyngeal carcinoma patients has important clinical significance for clinical efficacy observation and prognosis judgment.