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目的 探讨胸部肿瘤立体定向放射治疗 (SRT)的疗效及有关影响因素。方法 1997年 10月至1998年 12月胸部肿瘤患者 4 1例 ,4 8个病灶。采用STAR 10 0 0型立体定向放射治疗系统进行治疗。单靶点照射 35个病灶 ,多靶点照射 13个病灶。单次剂量 5～ 10Gy ,总剂量 2 4～ 4 4Gy ,中位剂量 37Gy。结果 立体定向放射治疗后 1～ 5月 31例患者 38个病灶复查了CT或MRI ,CR 11个病灶、PR 13个病灶 ,SD 8个病灶 ,总有效率达 84 .2 % ,PD 6个病灶。随访 3～ 15月 ,11例患者死亡 ,其中 7例死于远处转移 ,4例死于局部病变进展。余患者病情均稳定生存。结论 立体定向放射治疗是胸部肿瘤的有效治疗方法 ,特别是对于体积较小(≤ 3cm)、位于纵隔、肺门、椎旁及上肺的疗效较好。高剂量照射有助于提高局部控制率。
Objective To investigate the efficacy and related factors of stereotactic radiotherapy (SRT) in thoracic tumors. Methods From October 1997 to December 1998, 41 patients with chest tumor and 48 lesions were included. STAR 10 0 stereotactic radiotherapy system for treatment. Single target irradiation 35 lesions, multiple targets irradiation 13 lesions. A single dose of 5 ~ 10Gy, a total dose of 24 ~ 4 4Gy, the median dose of 37Gy. Results From January to May after stereotactic radiotherapy, 38 lesions of 31 patients were examined by CT or MRI, CR 11 lesions, PR 13 lesions and SD 8 lesions with a total effective rate of 84.2% and PD of 6 lesions . From March to May, 11 patients died, of whom 7 died of distant metastases and 4 died of local lesions. The remaining patients stable condition of survival. Conclusion Stereotactic radiotherapy is an effective treatment for thoracic tumors, especially for small size (≤ 3cm), located in the mediastinum, hilar, paravertebral and upper lung. High doses of radiation help to improve the local control rate.