目的考察复方健肾颗粒对高脂高糖饮食联合小剂量链脲佐菌素(STZ)致糖尿病肾病大鼠的药效学指标的影响,并初步探讨其机制。方法通过高脂高糖饮食联合小剂量STZ进行2型糖尿病肾病动物造模。通过测定空腹血糖(FBG)、血肌酐(Scr)、尿素氮(BUN)、糖化血红蛋白(GHb)、总胆固醇(TC)、三酰甘油(TG)、超氧化物歧化酶(SOD)、丙二醛(MDA)等指标观察其药效,考察其对肾脏病理改变的影响。通过ELISA法测定单核细胞趋化因子-1(MCP-1)、细胞间黏附分子-1(ICAM-1)、白细胞介素-6(IL-6)水平,初步探讨其作用机制。结果与模型组相比,复方健肾颗粒各组大鼠体质量均显著增加(P<0.01),大鼠饮食量、饮水量、尿量、尿蛋白定量显著降低(P<0.05、0.01),FBG值均下降(P<0.05、0.01),Scr均下降(P<0.01),BUN均下降(P<0.05、0.01),GHb水平显著下降(P<0.05、0.01),TC、TG、MDA水平显著下降(P<0.01),SOD显著升高(P<0.01),IL-6、MCP-1、ICAM-1水平下降显著(P<0.01)。结论复方健肾颗粒具有一定的降血糖、调血脂、抗氧化作用,能够保护肾脏的功能,其作用机制可能与MCP-1、ICAM-1、IL-6等炎症通路有关。 Objective To investigate the effect of compound jianshen granule on the pharmacodynamic parameters in rats with diabetic nephropathy induced by high-fat and high-sugar diet combined with low-dose streptozotocin (STZ), and to explore its mechanism. Methods Animal model of type 2 diabetic nephropathy was established by high fat and high glucose diet combined with low dose of STZ. The serum levels of FBG, Scr, BUN, GHb, TC, TG, SOD, Aldehyde (MDA) and other indicators observed its efficacy, investigate its impact on renal pathological changes. The levels of MCP-1, ICAM-1 and IL-6 were measured by ELISA, and the possible mechanism was explored. Results Compared with the model group, the body weight of rats in each group was significantly increased (P <0.01), and the dietary intake, water intake, urine output and urinary protein in rats were significantly decreased (P <0.05, 0.01) (P <0.05, 0.01), Scr decreased (P <0.01), BUN decreased (P <0.05, 0.01), GHb level decreased significantly (P <0.01), the level of SOD was significantly increased (P <0.01), the levels of IL-6, MCP-1 and ICAM-1 were significantly decreased (P <0.01). CONCLUSION Fufang Jianshen Granule has certain hypoglycemic, lipid-lowering and anti-oxidant effects and can protect renal function. Its mechanism may be related to inflammatory pathways such as MCP-1, ICAM-1 and IL-6.